Diabetes Insipidus Treatment Guidelines
Also called arginine vasopressin or avp.
Diabetes insipidus treatment guidelines. Patient unable to maintain oral fluid intake urine output higher than fluid intake hypernatremia. Consideration should be given to. Baseline investigations should include urea and electrolytes full ward test of urine and paired serum and urine osmolality. Diabetes insipidus is present when the serum osmolality is raised 295milliosmol kg with inappropriately dilute urine urine osmolality 700milliosmol kg.
Replacement of previous and ongoing fluid losses is also important. Central diabetes insipidus di due to reduced synthesis or release of arginine vasopressin avp from the hypothalamo pituitary axis. The major symptoms of central diabetes insipidus di are polyuria nocturia and polydipsia due to the concentrating defect. Most patients with diabetes insipidus di can drink enough fluid to replace their urine losses.
The recommendations are based on an extensive review of the clinical diabetes literature. Cranial diabetes insipidus is considered mild if you produce approximately 3 to 4 litres of urine over 24 hours. Treatment of this disorder is primarily aimed at decreasing the urine output usually by increasing the activity of antidiuretic hormone adh. If this is the case you may be able to ease your symptoms by increasing the amount of water you drink to avoid dehydration.
And nephrogenic di due to renal inse. This guideline has been written to aid in the diagnosis post operative management monitoring and potential complications of diabetes insipidus. Wear a medical alert bracelet or carry a medical alert card in your wallet. Maintenance of water balance.
Repeat the dose when urine output is between 200 and 250 ml h for 2 h with osmolality 200 mosm kg or urinary specific gravity 1005. Specific treatment for diabetes insipidus will be determined by your physician based on. Starting dose 1 2 μg. Your age overall health and medical history extent of the disease your tolerance for specific medications procedures or therapies expectations for the course of the disease your opinion or preference.
It also includes an algorithm for the management of a high urine output and a four hourly fluid balance chart. As long as you take your medication and have access to water when the medication s effects wear. Mild cranial diabetes insipidus may not require any medical treatment. If you have a medical emergency a health.
When oral intake is inadequate and hypernatremia is present replace losses with dextrose and water.